Fat Mobilizers and Their Unique Fat Burning Abilities There are physiological differences in fat cells, depending upon where they are located in the body. Fat cells located in the gut (visceral adipocytes) differ from fat cells located in the lower regions of the body (hips, thighs, lovehandles). Fat cells within the stomach contain a lot of beta-receptors. These cells respond to release fat when stimulated by the classic “fat-burners,” such as caffeine, ephedrine, and synephrine. These compounds stimulate lipolysis specifically by increasing norepinephrine delivery to the visceral fat cells and catecholamine secretion that activates the beta-receptors and increases CAMP within cells. However, fat cells located around the hips, and lovehandles characteristically contain very few beta-receptors and respond poorly to catecholamine release that is induced by exercise and beta-stimulants. However, these lower body fat cells contain a lot of alpha adrenoreceptors. Alpha-receptors are tricky and obstinate if you want them to release their fat stores. When stimulated, these receptors activate other proteins that inhibit adenylcyclase, thus antagonizing the ability of beta-adrenoreceptors to boost CAMP generation, and therefore, shut down the usual fat mobilization process. Basically, when taking caffeine, ephedrine, and synephrine supplements in an effort to stimulate fat loss, the alpha-receptors on lower-body fat cells say “No! No fat mobilization for you!” Fat cells within the lower half of the body contain a higher concentration of alpha-receptors and lower concentration of beta-receptors. Therefore, they are quite resistant to lipolysis. Women characteristically carry more fat on their hips and thighs than men do, and this difference in fat cell structure is one reason why most women have a tougher battle with fat loss…Until Now!

Apoptosis – A Novel Approach to Weight Loss

Hi-Tech has recognized for years that the active components in Hi-Tech’s fat loss products exerted their influence on fat loss through mechanisms of action attributable to increased lipolysis, decreased Lipogenesis, and more metabolically desirable fat mobilization. However, over the past five years of Research and Development, Hi-Tech began testing a theory that some of the beneficial effects of Lipodrene® and Stimerex-ES® were also actually due to their effect on elimination of entire fat cells, or apoptosis. Apoptosis is a form of cell suicide that plays a vital role in the maintenance of cellular homeostasis, but for weigh loss it causes cell death (specifically, fat cell death). It was once believed that the total number of adipocytes (fat cells) remained fairly constant over one’s lifetime; however studies over the last ten years have shown that adipocytes can be both lost and gained, and it is becoming increasingly recognized that fat cells have a finite life cycle and can be eliminated by apoptosis.

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