N-methyl-phenylethylamine – is another isolated amine from acacia rigidula that is both for stimulating fat burning and energizing effects. This is the N-methyl derivative of the compound B-Phenylethylamine. This is a very potent compound for all who lack a chemistry degree.

Methylsynephrine – is phenolic B-Phenylethylamine found in Acacia Rigidula and some cacti, which produces considerable nervous system stimulation (CNS). With Hi-Tech’s research over the past five years on Acacia Rigidula (as Thermo-Rx®), we have identified and isolated several key phenylethylamine alkaloids. The newest of which is methylsynephrine. The alkaloids from the acacia rigidula are biologically and physiologically similar to those found in ephedra, and possess properties that are shared with ephedra alkaloids. Scientifically, this is in part due to the similarities in pharmacokinetics and pharmacodynamics. The most obvious similarity is that acacia alkaloids, like the ephedra alkaloids, readily pass into the brain. The main factor governing the transfer of small molecules into the central nervous system is lipophilicity. The distribution of drugs and/or compounds into the CNS from the blood is unique, because functional barriers are present that restrict entry of drugs into this critical site. One reason for this is that the brain capillary endothelial cells have continuous tight junctions; therefore, drug penetration into the brain depends on transcellular rather than paracellular transport between cells. The unique characteristics of percipaillary gilial cells also contribute to the blood-brain barrier. At the choroids plexus, a similar blood-cerebrospinal fluid (CSF) barrier is present, except that it is epithelila cells that are joined by tight junctions rather than endothelial cells. As a result, the lipid solubility of the nonionized and unbound species of the drug is an important determinant of its uptake by the brain; the more lipophilic it is, the more likely it is to cross the blood-brain barrier. This situation is used in drugs design to alter the brain distribution, which is the case with drugs like amphetamine, phentermine, and benzphetamine. As you can see from the comparison of the structures of ephedrine, norephedrine, and methylsynephrine they all possess the b-methyl substituent of the aliphatic sidechain, which is characteristic of ephedrine and its congeners, as well as methylsynephrine, thus further increasing lipophilicity.

What is a suitable substitute for ephedra? How about another beta agonist? Methylsynephrine is just the answer that the industry has been waiting on for years! The sympathetic nervous system is involved in the regulation of energy. Therefore, pharmacological manipulation of the system offers a mechanism of targeting a reduction in excess body fat stores. Many beta-adrenergic agonists are known to increase muscle mass while concurrently decreasing fat mass. Prolonged treatment with sympathomimetic compounds reduces energy intake and increases energy expenditure. The beta 2&3 receptors appear to be responsible for the lipolytic and thermogenic effects of adrenergic agents, while interaction with beta-1 and to a much lesser extent, beta-2 control cardiac effects. Accordingly, the ideal fat loss compound would be one identical to acacia rigidula and especially methylsynephrine. Until now, there has never been a beta-adrenergic compound like methylsynephrine that can stimulate lipolysis and increase resting metabolic rate like ephedra.

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