New research is revealing some alarming concerns over the safety of Statin agents and questioning their effectiveness in a high percentage of patients taking these drugs.

How do Statins Work? The process of producing cholesterol begins with a two carbon molecule, acetyl-CoA, known as the "building block of life." Acetyl-CoA molecules combine to form hydroxymethyl glutaric acid (HMG). The enyme HMG-CoA reductase is required for mevalonate to be produced from HMG-CoA reductase. Statin drugs inhibit this enzyme and that is why they are known as HMG-CoA reductase inhibitors. This is the reason for the reported numerous side effects.

Statin drugs don't just inhibit the production of cholesterol. Statins inhibit the production of an entire group of intermediary enzymes and molecules that have essential biochemical functions. The mevalonate chain produces 3 end products and one of those is Cholesterol. Ubiquinone and dolichol are the others.

Ubiquinone also known as Co-Enzyme Q10 is an essential cellular nutrient formed in the mitochondria and is necessary for ATP production, functioning as an electron transporter to cytochrome oxidase, the primary respiratory enzyme. High levels of Co-Q10 are required by the heart to function. Ubiquinone, a form of Co-Q10 is in all cell membranes where it plays a vital role in maintaining proper cell membrane structure for nerves and muscles to function. Reduction in serum Ubiquinone levels have been described after statin therapy.( Mabuchi H, et al, J Atherosclero Thromb. 2005; 12(2) : 111-9)

Studies have shown that the use of statin agents for cholesterol control will reduce the level of co-enzyme q-10 by up to 40%. It appears that these statin agents, by altering membrane function actually also impair energy transport to these muscles necessary to keep them functioning properly. Co-Q10 deficiency can cause muscle wasting, pain and weakness and heart failure (the heart is a muscle!).

Proteins are synthesized within the membranes of the endoplasmic reticulum. This complex creation of peptides is directed by dolichol phosphate. The Dolichols are also critical in the assembly of glycoproteins, which allow complex protein structures to fold and interact with receptors and membranes. Dolichol-mediated processes create complex neuropeptides, and mechanisms critical in cellular communication, identification, and immune function. The reality of Dolichol inhibition by statin agents is evident and the resultant turmoil in cellular function is not unexpected. It is also not unexpected that altered cognition and abnormal behavior can result from statin induced neuropeptide formation.

Another common side effect associated with statin agents when used to dramatically reduce cholesterol levels are the neurodegenerative type diseases, almost like Lou Gehrig's disease or Multiple sclerosis, and this is because there is damage to the cellular membranes that make up the insulation around the nerves. It is like electrical wiring in an old house where the insulation around the wire has broken down leaving exposed wiring. These poorly functioning nerves and membranes result in muscle aches/pains as well as decreased strength and decreased nerve function. Memory and thought process may also be severely affected.

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