There are some diseases that we never really knew where it started or where it came from. It just mysteriously appears. I have made a list of mysterious disease that even medicine sometimes couldn't explain.

• Morgellons Disease

A very mysterious skin disorder has cropped up again just recently. It is said to have a creepy-crawly feeling on the skin and has an odd multi-colored fibrous filaments protruding from an open wound. It can sometimes be blamed as psychotic delusions but some medical communities say the symptoms are very real. Canada, Australia, UK, and the Netherlands are said to be affected by the disease. But majority of the reported cases came from Florida, California, and Texas.

• Chronic Fatigue Syndrome

The classic MUPS or medically unexplained physical symptoms, it is the feeling of more than just being tired. Most patients often get bed-ridden for days. This disease is debilitating and can't be resolved by bed rest. It can even persist for years, the cause has never been identified yet and no specific diagnostic procedures are available.

• Creutzfeldt-Jakob Disease

A rare brain disorder, also known as the Mad-Cow Disease, is contracted from eating an infected beef. It can be fatal and quick acting, this disease develops even the doctors couldn't possibly figure out and prevent. The incidence of death in the United States was said to be higher in patients aging from 55-65 years old.

• Schizophrenia

A mental disorder which is considered the most puzzling, the patient suffers from inability to distinguish between fantasy and reality. The patients can be delusional, has hallucinations, disorganized speech, and lack of motivation or emotion. The disease has no defining medical tests.

• Autoimmune Disorders

A disease that treats the normal body function and organs as the enemy such as Lupus and Multiple Sclerosis; they usually are debilitating, chronic, and it usually don't have a cure and treatment is symptom-based.

• Pica

Insatiable urge to eat non-food substances like paper, glue, clay, and dirt. This disease has no cause and no cure. Pica in children can be very dangerous, sometimes children eat paints that contain lead and they may suffer from lead poisoning leading to brain damage.

• Avian Flu

A bird carried powerful flu virus, and mutates into a strain that affects humans. The death rate is actually 50% mostly by humans handling infected birds.

• Common Cold

Common colds maybe a common disease but still mysteriously can't be treated by antibiotics but a simple chicken soup and rest can do the trick. The doctors actually know a little about the nose-running, cough-inducing cold, and the root cause.

• Alzheimer's Disease

A degenerative brain disorder which manifests differently among different people. The root cause can't be determined or understood and it can't be treated effectively. Patients' disease progresses from a mild cognitive impairment to advanced dementia.

• AIDS

An acquired immune deficiency syndrome still has no cure. It is the most potent killer most especially in developing countries. We all know it started from monkeys and jumped into humans.