When the yerba is harvested, the branches are dried sometimes with a wood fire, imparting a smoky flavour. Then the leaves and sometimes the twigs are broken up.

Researchers at Florida International University in Miami have found that yerba mate does contain caffeine, but some people seem to tolerate a mate drink better than coffee or tea. This is expected since mate contains different chemicals (other than caffeine) than tea or coffee.

From reports of personal experience with mate, its physiological effects are similar to (yet distinct from) more widespread caffeinated beverages like coffee, tea, or guarana drinks. Users report a mental state of wakefulness, focus and alertness reminiscent of most stimulants, but often remark on mate's unique lack of the negative effects typically created by other such compounds, such as anxiety, diarrhea, "jitteriness", and heart palpitations.

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