Concern over the slow environmental degradation of fluorocarbons has led to reduced usage of many of these substances. Some, such as carbon tetrachloride, were once available for public use, but are now much more tightly regulated. Most fluorocarbon solvents now have a much more limited range of industrial uses.

Some fluorocarbons (such as Freon) have a particularly bad reputation, however, due to their use as refrigerants and propellants. These have commonly contained chlorine in addition to fluorine. While the strong fluorine-carbon bonds make these substances highly resistant to environmental degradation, the addition of chlorine makes them highly reactive and destructive to the earth’s ozone layer. For this reason, the use of chlorofluorocarbons has been largely discontinued.

Despite environmental concerns, some fluorocarbons (such as fluoroplastics and fluoroeslastomers) are still in common use. One example is Teflon, which is a very common component of non-stick cookware.

The Use of Fluorine in Pharmaceuticals

One increasingly widespread application of specialty fluorochemicals is in the pharmaceutical industry, in which the ability of fluorine to improve the existing properties of other chemicals makes it enormously useful.

Simply by adding fluorine, the pharmacological properties of a drug can be improved in potency quite significantly, allowing for the use of lower doses to achieve the same effect as was previously gained.

Aside from this highly desirable property, another important advantage of adding fluorine to pharmaceuticals is that the shape of the resulting fluorochemical is largely unchanged. This is particularly important because the bioactivity of many drugs is highly dependent on the shape of the chemical compound.

One drawback, however, is the fact that the addition of fluorine improves the stability of pharmaceuticals. While this is an enormous advantage for most other specialty fluorochemical applications, in the pharmaceutical industry this is not always the case, because in some cases, improving the stability of a drug can reduce its metabolic degradation.

Currently, up to 50% of all modern pharmaceuticals contain fluorine. These include anesthetics, antidepressants, antifungals and antibiotics, antacids, cholesterol lowering agents, steroids and other anti-inflammatory agents, and certain types of anticancer chemotherapeutic drugs.

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