Enemies:
Lions are capable of hunting mature buffalo which may take just a few minutes to pull down or even a couple hours with less experienced lion. Spotted hyena and leopard normally hunt the young calves which are less of a risk as buffalo often team together and put up a good fight and are very capable of killing lions and the other predators.
Disease:
Cape buffalo have a very low white blood cell count when compared to other animals which results in a weak immune system and makes them susceptible to diseases such as foot and mouth disease and bovine tuberculoses. The tuberculosis is extremely contagious and by sharing the same drinking water it spreads very quickly through the herd. Buffalo that have T.B. can live for many years as long as they aren’t malnutritioned. During dry seasons or drought the effects of the T.B. may kill many buffalo.
Predators such as lion that hunt T.B. infected buffalo are also at risk after eating the meat of these animals.
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