As MCL is very similar to several other lymphoma types, imunologic tests are recommended for a correct diagnosis. One of this kind of tests is Immunophenotyping which determine what kind of surface molecules are present on cells, and which is the exact type of lymphoma, from a tissue sample.

When the diagnosis is sure it must be known that mantle cell lymphoma has already spread into many other tissues such as the lymph nodes, spleen, bone marrow or to the ring of adenoid, palatine and lingual tonsils at the back of the mouth or even to the gastrointestinal tract. If the MCL spread to the colon it is diagnosed as multiple lymphomatous polyposis.

The treatment for MCL is established depending on the type of MCL and it stage.

There is no standard treatment for MCL patients. The patients diagnosed with MCL have been treated with surgery, radiation, single drug or combination chemotherapy and stem cell transplants. The most common chemotherapy regimens for treating MCL includes the drugs: Cyclophosphamide (cytoxan, neosar), adriamycin (doxorubicin or Hydroxydoxorubicin), vincristine (Oncovin), and Prednisone and it is called CHOP.

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