A recent clinical trial has given further weight to the acceptance that supplemented dietary nucleotides, essential building blocks, can support the rapid production of new cells, which is beneficial for adult immunity and gut health.

This 2005 clinical trial, the effectiveness of a nucleotide supplement in the management of individuals with Irritable Bowel Syndrome (IBS), was sponsored by a grant from the Dept Trade and Industry, and conducted at the University of East London, under control of Professor Christine Dancey. Professor Dancey heads the Dept of Psychology and the Chronic Illness Research Team (CIRT) and is the co-founder of IBS Network.

IBS is one of the most prevalent chronic illnesses, and present’s itself through a number of symptoms. The most severe cases generally include the following symptoms. Abdominal pain, varying from mild to extremely severe; this is the symptom which causes most sufferers to seek medical help. Diarrhoea, constipation – or worse, an alternation of both are common. Urgency to have a bowel movement – also affects people with constipation as well as diarrhoea, and a feeling of incomplete evacuation.

Current medical treatments are directed at symptomatic relief, and although these - and psychological treatments - can help relieve IBS, there is no one treatment which has been shown to be lastingly effective. Although IBS is not a life-threatening disease, the symptoms and the effects of the symptoms on daily life can have a great impact on sufferers (Silk, 2001). IBS is also associated with large healthcare and economic costs in terms of hospital investigations, repeated visits to GPs, prescription medicines, and loss of time from work (Creed et al 2001).

Since there is no cure for IBS, people with IBS attempt to control their disorder by taking both prescribed medicines and over-the-counter remedies, together with dietary control. Some are living on extremely restricted, and therefore unhealthy, dietary regimes. In an earlier study of people with IBS, Dancey & Backhouse (1993) found that 14% of their sample (N=148) ate very restricted diets hoping that this would cure their IBS. However most of their sample (70%) said that they were trying to follow a healthy diet with plenty of fruit and vegetables.

This clinical trial was carried out to determine whether a nucleotide supplement, could improve the symptoms of IBS. Nucleotides are substances which are synthesised endogenously, and have important effects on the growth and development of cells which have a rapid turnover, such as those in the immune system and the gastrointestinal tract. In healthy people, dietary nucleotides are probably not essential, and in fact most will be metabolised and rapidly excreted from the system. However, under certain circumstances e.g. in the sub-well, diseased, or under conditions of stress or poor diet, dietary nucleotides may be what Maldonado et al (2001) call “semi-essential”, optimising the function of the gastrointestinal and immune systems. In relation to the gastrointestinal system work has shown that dietary nucleotides enhance the intestinal absorption of iron (Cosgrove 1998).

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